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Thus, the altered catalase-peroxidase provides high-level resistance to isoniazid, while retaining a level of oxidative protection that is sufficient to enable the organism to maintain detoxifying activity against host antibacterial radicals.

3 if the tuberculosis is resistant to both isoniazid and rifampin, yet susceptible to ethionamide, ethionamide should be accompanied by at least two other drugs to which the m.

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a review by menzies et al 41 found that in patients with baseline isoniazid monoresistance, a longer duration of rifampicin, use of streptomycin, daily therapy initially, and treatment with a greater number of effective drugs were associated with reduced risk of adr.

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